Citation: Xiang Hong LI, Yu Fen ZHAO. Regulation of Cleavage Activity of Ser-His Dipeptide on DNA by Phosphorylation[J]. Chinese Chemical Letters, ;1997, 8(7): 611-612. shu

Regulation of Cleavage Activity of Ser-His Dipeptide on DNA by Phosphorylation

Department of Chemistry, Tsinghun University Beijing 100084

Received Date: 3 February 1997

Fund Project: The authors wish to acknowledge the financial support from the National Natural Science Foundation of China the National Science and Technology Committee.

The cleavage reactions of Ser-His and its N-terminal phosphorylated form-N-(O,O-diisopropyl) phosphoryl seryl-histidine (DIPP-Ser-His) were studied on DNA.It was found that the phosphorylation of Ser-His caused the lost of the cleavage activity on DNA.The result might give some clue on the regulation of the activity of protein by phosphorylation.
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