引用本文:
Song Qing WANG, Lin FANG, Xiu Jie LIU, Kang ZHAO. Design,Synthesis,and Hypnotic Activity of Pyrazolo[1,5-a]pyrimidine Derivatives[J]. Chinese Chemical Letters,
2004, 15(8): 885-888.
Citation: Song Qing WANG, Lin FANG, Xiu Jie LIU, Kang ZHAO. Design,Synthesis,and Hypnotic Activity of Pyrazolo[1,5-a]pyrimidine Derivatives[J]. Chinese Chemical Letters, 2004, 15(8): 885-888.
Citation: Song Qing WANG, Lin FANG, Xiu Jie LIU, Kang ZHAO. Design,Synthesis,and Hypnotic Activity of Pyrazolo[1,5-a]pyrimidine Derivatives[J]. Chinese Chemical Letters, 2004, 15(8): 885-888.
Design,Synthesis,and Hypnotic Activity of Pyrazolo[1,5-a]pyrimidine Derivatives
摘要:
On the basis of the Zaleplon structure, novel pyrazolo[1,5-a]pyrimidines were designed and prepared for studies on their hypnotic activity.This paper reported the synthesis of twelve new 5-methyl-7-substituted-pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives by using simple starting materials such as propane dinitrile and triethyl orthoformate.The structures of the derived target compounds were confirmed by their IR and 1H-NMR spectroscopic data.The preliminary pharmacological evaluations indicated that some compounds showed hypnotic activity, while derivative 1c was the most potent one.
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关键词:
- GABA
- / hypnotic drug
- / synthesis
- / pyrazolo[1,5-a]pyrimidines
English
Design,Synthesis,and Hypnotic Activity of Pyrazolo[1,5-a]pyrimidine Derivatives
Abstract:
On the basis of the Zaleplon structure, novel pyrazolo[1,5-a]pyrimidines were designed and prepared for studies on their hypnotic activity.This paper reported the synthesis of twelve new 5-methyl-7-substituted-pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives by using simple starting materials such as propane dinitrile and triethyl orthoformate.The structures of the derived target compounds were confirmed by their IR and 1H-NMR spectroscopic data.The preliminary pharmacological evaluations indicated that some compounds showed hypnotic activity, while derivative 1c was the most potent one.
-
Key words:
- GABA
- / hypnotic drug
- / synthesis
- / pyrazolo[1,5-a]pyrimidines
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