Citation: Qiong You WU, Xun ZHU, JIN Qiao WAN, Fan Qi QU, Ling PENG. Synthesis of a Photolabeling Probe for the Study of Antiviral Mechanism of Ribavirin[J]. Chinese Chemical Letters, ;2004, 15(8): 907-910. shu

Synthesis of a Photolabeling Probe for the Study of Antiviral Mechanism of Ribavirin

Qiong You WU ^1, ,
Xun ZHU ² ,
JIN Qiao WAN ¹ ,
Fan Qi QU ¹ ,
Ling PENG ^1,3

1.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072;
2.
Department of Material Science and Engineering, Wuhan Institute of Chemical Technology;
3.
AFMB CNRS UMR 6098, Université Aix-Marseille II, 163, avenue de Luminy 13288 Marseille, France

Received Date: 14 July 2003

Ribavirin has been used in urgency to treat SARS patients recently.In order to study its antiviral mechanism by photolabeling approach, we have synthesized and characterized 5-azido-1-(-D-ribofuranosyl-1,2,4-triazole-3-carboxiamide 1 as a photolabeling probe of ribavirin.The azidotriazole nucleoside showed rapid and clean photochemical reaction, suggesting that 1 is a promising probe to study the antiviral mechanism of ribarivin by photolabeling.
- Ribavirin,
- photolabeling probe of ribavirin,
- azidotriazole nucleoside,
- azole nucleosides,
- photolabeling
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