Citation: Gang XU, Cheng Cai AN, Jun FENG, Yun Xiang CI, Jin Hua TIAN, Zhang Liang CHENI. The Study of Anti-tumor Activity of Trichosanthin by Cyclic Voltammogram[J]. Chinese Chemical Letters, ;2000, 11(7): 597-600. shu

The Study of Anti-tumor Activity of Trichosanthin by Cyclic Voltammogram

a National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871;
b College of Chemistry and Molecular Engineering, Peking University, Beijing 100871

Received Date: 17 May 1999
Revised Date: 12 April 2000

The anti-tumor activity of Trichosanthin (TCS) has been frequently reported in recent years. In our experiments, electrochemical methods were applied to detect the effects of TCS on human leukemia cells U937. 50μg/ml TCS treatment for 40 hours can cause irreversible negative effects on the viability of U937 cells. This effect largely depends on the concentration of TCS and the time period of treatment.
- Trichosanthin (TCS),
- U937 cells,
- cyclic voltammogram,
- Ribosome Inactivating Proteins (RIPs)
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