Citation: Ai Dapeng, Ju Xiulian, Liu Genyan. Isoxazoline Parasiticides Acted on Ionotropic GABA Receptors[J]. Chemistry, ;2020, 83(11): 986-996. shu

Isoxazoline Parasiticides Acted on Ionotropic GABA Receptors

Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205

Corresponding author: Liu Genyan, liugenyan@wit.edu.cn
Received Date: 16 May 2020
Accepted Date: 29 July 2020

Figures(5)

The insect ionotropic γ-amino-butyric acid (GABA) receptors are an important class of insecticide targets, and isoxazoline analogues are a novel type of insecticides/parasiticides that acted on this target. Since the first isoxazoline parasiticide fluralaner has been identified, novel isoxazolines such as afoxalaner, sarolaner, lotilaner, and fluxametamide have been successively reported based on their effective insecticidal activity and excellent safety. In this paper, we mainly reviewed the latest research progress in the field of isoxazoline insecticides, especially focusing on their chemical structures, insecticidal activities, mechanisms of action, biological metabolisms, and safeties. Moreover, the limitations of the application of isoxazoline insecticides/parasiticides were discussed. Finally, the application prospects and development trends of these isoxazolines in the prevention and management of agricultural pests and diseases were also pointed out.
- Ionotropic GABA receptor,
- Isoxazoline,
- Fluralaner,
- Parasiticide,
- Insecticide
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沈阳化工大学材料科学与工程学院沈阳 110142