Citation: Xin Sheng LEI, Zong Ru GUO, Ling Bo QU, Qi Qing ZHU. Selective Cyclooxygenase-2 Inhibitors:Design and Synthesis[J]. Chinese Chemical Letters, ;1999, 10(6): 469-472. shu

Selective Cyclooxygenase-2 Inhibitors:Design and Synthesis

Institute of Materia Medica, Chinese Academy of Medical SciencesAnd Peking Union Medical College, Beijing 100050

Received Date: 24 March 1999

Fund Project: This project supported by the National Natural Science Foundation of China. No 39770877.

The discovery of COX-2 provides a novel target developing more ettective NSAIDs with fewer side effects. On the basis of results from the structure-activity relationships (SAR) of selective COX-2 inhibitors. we have designed and synthesized some promising compounds.
- Cyclooxygenase,
- cyclooxygenase-2,
- inhibitor selective
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