Citation: Chun Li, Wu Yan Zhang, Ji Yu Guo, Xiao Tian Liang. Studies on Agarofurans VIII.Synthesis of the Metabolites of 4-Butyl-α-agarofuran[J]. Chinese Chemical Letters, ;2002, 13(1): 19-22. shu

Studies on Agarofurans VIII.Synthesis of the Metabolites of 4-Butyl-α-agarofuran

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received Date: 15 May 2001

Fund Project: This work was supported by the National Natural Science Foundation of China. We also appreciate the heavy involvement of Dr. Wen Jiang Zhang in the work on metabolism studies and spectrometric identification of the metabolites.

The structures of five metabolites (2-6) of agarofuran 1 were confirmed by synthesis.The configuration of the secondary hydroxyl in 7 was determined by Horeau's method.The configuration of C-2 in compound 4 and 5 was determined by their stereochemistry and NMR.
- Agarofuran,
- metabolite,
- synthesis
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