Citation: Ming Zhong CAI, Hong ZHAO. Stereoselective Synthesis of (E)-1,3-Enynyl Bromides via Pd/Cu-catalyzed Cross-coupling Reaction of (Z)-α-Bromovinylstannanes[J]. Chinese Chemical Letters, ;2004, 15(10): 1157-1160. shu

Stereoselective Synthesis of (E)-1,3-Enynyl Bromides via Pd/Cu-catalyzed Cross-coupling Reaction of (Z)-α-Bromovinylstannanes

Ming Zhong CAI ^1, ,
Hong ZHAO ²

1.
Department of Chemistry, Jiangxi Normal University, Nanchang 330027;
2.
Department of Pharmacy, Guangdong Pharmaceutical College, Guangzhou 510240

Received Date: 1 September 2003

Fund Project: We thank the National Natural Science Foundation of China(Project 20062002) and Natural Science Foundation of Jiangxi Province for financial support.

(Z)-α-Bromovinylstannanes undergo the cross-coupling reaction with alkynyl iodides in the presence of Pd(PPh₃)₄ and Cul in THF at room temperature to afford stereoselectively (E)-1, 3-enynyl bromides in good yields
- (Z)-α-Bromovinylstannane,
- palladium,
- cross-coupling,
- stereoselective synthesis
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