Citation: Yi Hua YANG, Yu Lin LI. The First Total Synthesis of Saurufuran B[J]. Chinese Chemical Letters, ;2006, 17(10): 1287-1288. shu

The First Total Synthesis of Saurufuran B

Yi Hua YANG ,
Yu Lin LI

State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000

Received Date: 10 April 2006

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No. 20072012) and the Special Research Grant for Doctoral Sites in Chinese Universities (No. 20010730001).

First total synthesis of saurufuran B 1, a furanoditerpene, from (E, E)-farnesol 2 and citraconic anhydride 3 through thirteen steps is described. Our work involves two key steps:(1)High regioselective alkylation of 2-(tert-butyldimethylsiloxy)-4-methylfuran 6 with allylic iodides 5 in the presence of silver trifluoroacetate¹ and (2) Conversion of substituted γ-lactone 7 into furan derivative 8².
- Saurufuran B,
- first total synthesis,
- furanoditerpene,
- regioselective alkylation
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