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Citation: Bingxue Zhang, Bo Peng, Liming Yuan. Study on Preparation and Separation Performance of L-Threonine Chiral Molecularly Imprinted Silica Gel Stationary Phase[J]. Chemistry, ;2021, 84(3): 267-272. shu

Study on Preparation and Separation Performance of L-Threonine Chiral Molecularly Imprinted Silica Gel Stationary Phase

Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, 650500

Corresponding author: Liming Yuan, yuan_limingpd@126.com
Received Date: 30 July 2020
Accepted Date: 2 November 2020

Figures(9)

Using the stacking silica beads method, silica sol as the raw material, and threonine (L-Thr) as the chiral source to construct a chiral environment, we prepared the inorganic mesoporous chiral silica balls stationary phase with chiral separation capabilities. Elemental analysis, infrared spectroscopy, transmission electron microscope, scanning electron microscopy, and nitrogen adsorption were used to characterize its structures. The separation of chiral isomers and benzene-based positional isomers on the stationary phase was carried out through high-performance liquid chromatography (HPLC). Nine racemic compounds and eight benzene position isomers were successfully separated. The L-Thr chiral molecularly imprinted silica gel stationary phase has certain feasibility in chiral separation and good separation performance in the separation of positional isomers, and its chromatographic repeatability is good.
- Chiral isomer,
- Benzene position isomer,
- Inorganic mesoporous silica ball,
- HPLC,
- Chiral separation
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