Citation: De Xin WANG, Rui HAN, Hong Yan LIU, Lei HUANG, Jun FU. An Efficient Synthesis and Screening of Osteostatin analogues byUsing Pooling Strategy[J]. Chinese Chemical Letters, ;1999, 10(10): 821-824. shu

An Efficient Synthesis and Screening of Osteostatin analogues byUsing Pooling Strategy

Institute of Materia Medica Chinese Academy of Medical Sciencesand Peking Union Medical College Beijing 100050

Received Date: 21 June 1999

Fund Project: Project supported by the National Natural Science Foundation of China (No.39770871)

An efficient synthesis and screening of twenty one osteostatin(OSN) analogues were achieved by using pooling strategy. Three analogues were found to retain almost the same activity of inhibiting bone resorption in rat as that of OSN. Therefore, it is possible to develop partially modified OSN surrogate with higher enzymic stability.
- Structure modification,
- pooling strategy,
- OSN analogues,
- osteoporosis
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