Citation: Wei Ping YIN, Tian Zeng ZHAO, Ling Jie GAO, Da Peng ZOU, Jian Xun KANG. A Novel Sesquiterpene Polyol Ester from Celastrus Angulatus and its Antitumor Activities[J]. Chinese Chemical Letters, ;1999, 10(6): 487-490. shu

A Novel Sesquiterpene Polyol Ester from Celastrus Angulatus and its Antitumor Activities

1.
Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450003;
2.
Centre of Instrumental Analysis, Zhengzhou University, Zhengzhou 450052

Received Date: 31 December 1998

Fund Project: The authors thank the National Cancer Institute (NCI), Developmental Therapeutics Program (Bethesda. MD) for in vitro test of our compound for cytotoxicity.

A new sesquiterpene polyol ester was isolated from the leaves of Celastrus angulatus. Its structure was determined as 1β, 2β,9α-triacetoxy-8α-(α-hydroxyl-isobutyryloxy)-15-benzoyloxy-4α-hydroxy-dihydroagarofuran by means of NMR, MS and IR spectral analysis. Preliminary biological study on antitumor activity revealed that this compound showed strong nonselective cytotoxicity against four of the NCI panel cell lines.
- Celastrus angulatus,
- sesquiterpene polyol ester,
- NMR,
- activities activities
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