Citation: De Xin FENG, Ru Yu C HEN, You HUANG. Regioselective and Stereoselective Synthesis of the 3-Aryl-4-phosphoryl-1, 2, 4-triazoline-5-ones[J]. Chinese Chemical Letters, ;2006, 17(9): 1145-1148. shu

Regioselective and Stereoselective Synthesis of the 3-Aryl-4-phosphoryl-1, 2, 4-triazoline-5-ones

Institute of Elemento-Organic Chemistry, National Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Received Date: 14 March 2006

Fund Project: The authors thank the NNSFC (No. 20172027) and the Natural Science Foundation of Tianjin (05YFJMJC00600) for financial support.

A novel and efficient route of synthesizing 1, 2, 4-triazoline-5-ones is reported. The title compounds can be prepared in high yield and purity by the one-pot oxidation and cyclization of 1-acylthiosemicarbazides. The reaction is regioselective and stereoselective. The reaction condition is mild.
- Triazoline,
- 1-acylthiosemicarbazides,
- regioselective,
- stereoselective,
- cyclization
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