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Citation: Ma Lianfeng, Li Huijing, Wu Yanchao. Base-Promoted Green Synthesis of Quinolinamide Derivatives[J]. Chemistry, ;2019, 82(6): 516-521. shu

Base-Promoted Green Synthesis of Quinolinamide Derivatives

School of Marine science and technology, Harbin Institute of Technology, Weihai 264209

Corresponding author: Wu Yanchao, morland_m@163
Received Date: 7 December 2018
Accepted Date: 18 February 2019

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Based on the consideration of economy and environmental protection, a new method for the synthesis of a series of quinolinamide derivatives from quinolinecarboxaldehyde and aromatic amines has been developed by using an inexpensive and easy-to-handle base as the promoter at room temperature. The effects of solvents, bases and substrates molar ratios on the reaction were examined to obtain the optimal reaction conditions, and a possible reaction mechanism was proposed. The reaction possesses many advantages such as mild conditions, simple treatment, good yields, and environmental friendliness.
- Room temperature,
- Base-promoted,
- Amidation,
- Quinolinamide,
- Environmental-friendly
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