Citation: Wei Shuo FANG, Qi Cheng FANG, Xiao Tian LIANG. The Ephemeral 10β-OH Trifluoromethanesulfonates of 7-Epi Paclitaxel Analogs-A New Example for Anchimeric Assistance[J]. Chinese Chemical Letters, ;1998, 9(1): 29-33. shu

The Ephemeral 10β-OH Trifluoromethanesulfonates of 7-Epi Paclitaxel Analogs-A New Example for Anchimeric Assistance

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received Date: 28 August 1997

Fund Project: This work is partly supported by The National Natural Science Foundation of China for W.S.Fang.

Two rearranged products, dienone 4 and 10-oxo product 5 were obtained upon at-tempted 10p-OSO₂CF₃ formation from 3. The formation of compound 5 can be explained by an-chimeric assistance of 7α-OH. Reduction of 4 yielding a 4-deacetyl product (12) also involves neighboring group participation.
- rearrange,
- anchimeric assistance,
- neighboring group participation
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