Citation: Mao Sheng CHENG, Rong Shi LI, George KENYON. A Solid Phase Synthesis of Chalcones by Claisen-Schmidt Condensations[J]. Chinese Chemical Letters, ;2000, 11(10): 851-854. shu

A Solid Phase Synthesis of Chalcones by Claisen-Schmidt Condensations

1.
Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110015;
2.
Department of Pharmaceutical Chemistry, University of California, San Francisco USA

Received Date: 6 April 2000

Fund Project: This work was supported by grants from the Advanced Research Projects Agency (MDA-972-91-.11013. N00014-90-2032) and the World Health Organization (WHO 940104).

In order to accelerate the development of relatively inexpensive antimalarials that are effective against chloroqtrine-resistant strains of Plasmodium falclparum, a methodology for the solid phase synthesis of chalcone (1 3-diphenyl-2-propen-1-one) analogues in reasonably high yields has been developed.
- Solid phase synthesis,
- chalcones,
- antimalarial
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