Citation: Jian Mei CUI, Da Li YIN. Synthesis and Resolution of 10, 11-Dihydro-10-hydroxycyproheptadine[J]. Chinese Chemical Letters, ;2006, 17(4): 444-446. shu

Synthesis and Resolution of 10, 11-Dihydro-10-hydroxycyproheptadine

Jian Mei CUI ,
Da Li YIN

Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050

Received Date: 23 November 2005

10, 11-Dihydro-10-hydroxycyproheptadine was synthesized in a new and facile synthetic route and resolved by L-(-)-2-(1, 3)-dioxo-1, 3-dihydroisoindol-2-yl)-propionic acid and D-(+)-tartaric acid, respectively. The free base of the two enantiomers has the same absolute specific rotation value.
- H₁ receptor antagonist,
- chiral center,
- racemate,
- resolution,
- specific rotation
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