Citation: Bo Lin LIN, Yao FU, Lei LIU, Qing Xiang GUO. Effects of Bases on the Stabilities of Nucleoside C4'Radicals[J]. Chinese Chemical Letters, ;2003, 14(10): 1073-1076. shu

Effects of Bases on the Stabilities of Nucleoside C4'Radicals

Department of Chemistry, University of Science and Technology of China, Hefei 230026

Received Date: 21 October 2002

Fund Project: We thank NNSFC (No.20272057) and the State Ministry of Education for the financial support.

C4'-H bond dissociation enthalpies of nucleosides were predicted using theoretical methods to a precision of 1-2 Kcal/mol. It was found that the stability of the C4'nucleoside radical is slightly dependent on the base. The orders of stability are dA < dG < dT < dC for deoxynucleosides and U < G < A≈C for nucleosides.
- Nucleoside,
- homolysis,
- bond energy,
- DNA lesion,
- substituent effect
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