Citation: Li Ya ZHU, Xiao Tian LIANG, Tai Shun LIN. SYNTHESIS OF 6-AMINO, 6-METHOXY AND 6-ETHOXY PURINENUCLEOSIDE DERIVATIVES[J]. Chinese Chemical Letters, ;1991, 3(8): 601-604. shu

SYNTHESIS OF 6-AMINO, 6-METHOXY AND 6-ETHOXY PURINENUCLEOSIDE DERIVATIVES

a Institute of Materia Medica Chinese Academy of Medical Sciences Beijing 100050;
b Department of Pharmacology Yale University School of Medicine New Haven CT 06510 U S A

Received Date: 4 September 1990

A convenient route for the conversion of inosine to the corresponding 6-amino, 6-methoxy and 6-ethoxy derivatives is reported. This conversion can be achieved by ammoniation or etherification of the 6-pyridinium intermediate(3) which can be readily produced under mild reaction conditions. The chemistry and characterization of these compounds are presented, A plausible mechanism of the reaction is proposed.
1. [1]
  Zan Chen , Yi Wang , Yuxuan Zhou , Yunlang Li , Rong Xiong , Wenting Huang , Huanfeng Jiang , Wanqing Wu . Selective synthesis of [6-6-7]/[6-6-6] core polycyclic heterocycles via Lewis acid-mediated cascade annulation of 1,6-enynols with aminonitriles. Chinese Chemical Letters, 2026, 37(6): 111718-. doi: 10.1016/j.cclet.2025.111718
2. [2]
  Zhengzheng LIU , Pengyun ZHANG , Chengri WANG , Shengli HUANG , Guoyu YANG . Synthesis, structure, and electrochemical properties of a sandwich-type {Co₆}-cluster-added germanotungstate. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1173-1179. doi: 10.11862/CJIC.20240039
3. [3]
  Shuwen SUN , Gaofeng WANG . Design and synthesis of a Zn(Ⅱ)-based coordination polymer as a fluorescent probe for trace monitoring 2, 4, 6-trinitrophenol. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 753-760. doi: 10.11862/CJIC.20240399
4. [4]
  Wenya DING , Fangfei XU , Jiayu GU , Xinran CHEN , Kai CHEN . Synthesis and crystal structure of three cucurbit[6]uril-cadmium supramolecular assemblies. Chinese Journal of Inorganic Chemistry, 2026, 42(4): 808-816. doi: 10.11862/CJIC.20260012
5. [5]
  Yupeng TANG , Haiying YANG , Fan JIN , Nan LI . Hydrogen storage properties of C₆S₆Li₆: A density functional theory study. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1827-1839. doi: 10.11862/CJIC.20240460
6. [6]
  Xue-Wen Wu , Bin-Bao Wang , Yu Qin , Yong-Xiang Huang , Muhammad Aurang Zeb , Bin Cheng , Xiao-Li Li , Chang-Bo Zheng , Wei-Lie Xiao . Diterpenoids with unexpected 5/6/6-fused ring system and its dimer from Strophioblachia glandulosa. Chinese Chemical Letters, 2025, 36(8): 110584-. doi: 10.1016/j.cclet.2024.110584
7. [7]
  Meijuan Chen , Liyun Zhao , Xianjin Shi , Wei Wang , Yu Huang , Lijuan Fu , Lijun Ma . Synthesis of carbon quantum dots decorating Bi₂MoO₆ microspherical heterostructure and its efficient photocatalytic degradation of antibiotic norfloxacin. Chinese Chemical Letters, 2024, 35(8): 109336-. doi: 10.1016/j.cclet.2023.109336
8. [8]
  Ruiyan CHEN , Yanping HE , Jian ZHANG . Synthesis and third-order nonlinear optical property of Ti₄L₆ cage-based metal-organic framework. Chinese Journal of Inorganic Chemistry, 2025, 41(10): 2149-2156. doi: 10.11862/CJIC.20250177
9. [9]
  Lian Yang , Guo-Cheng Liu , Na Xu , Zhong Zhang , Xiu-Li Wang , Yong-Ge Wei . Catalytic synthesis of quinones and visual intelligent portable colorimetric detection of phenols by a [Ag-AlMo₆]-nanosheet-based hybrid. Chinese Chemical Letters, 2026, 37(6): 112344-. doi: 10.1016/j.cclet.2025.112344
10. [10]
  Hanqi Zhang , Biao Gao , Yuanyuan Feng , Guijuan Zheng , Zhijun Liu , Lichun Kong , Junjun Liu , Haji Akber Aisa , Guangmin Yao . DFT calculations and dynamic NMR revealed the coalescent NMR phenomena of the 6/6/6/9 tetracyclic merosesquiterpenoids with an unprecedented 9,15-dioxatetracyclo[8.5.3.0^4,17.0^14,18]octadecane core skeleton. Chinese Chemical Letters, 2025, 36(9): 111234-. doi: 10.1016/j.cclet.2025.111234
11. [11]
  . . University Chemistry, 2024, 39(6): 0-0.
12. [12]
  . Cover and Table of Contents for Vol.41 No. 6. Acta Physico-Chimica Sinica, 2025, 41(6): -.
13. [13]
  . 第40卷第6期封面和目次. University Chemistry, 2025, 40(6): 0-0.
14. [14]
  Yongqing Zeng , Caijun Liang , Xin Lu , Lingxue Zhao , Fangting Wu , Tao Hou , Anting Zhao , Menglan Lv , Zhu Tao , Qing Li . Perfect separation of pyridine and 3-methylpyridine by cucurbit[6]uril. Chinese Chemical Letters, 2025, 36(9): 110807-. doi: 10.1016/j.cclet.2024.110807
15. [15]
  Wenxiong Yu , Chenyu Yang , Xian Feng , Chengshuo Shen . Scholl cyclization of [6]helicenes into negatively curved hexa[7]circulenes. Chinese Chemical Letters, 2025, 36(11): 110939-. doi: 10.1016/j.cclet.2025.110939
16. [16]
  Jiang-Feng Xing , Kang Li , Wan Xiang , Yang-Yang Ju , Xin-Jing Zhao , Xiao-Hui Ma , Mei-Lin Zhang , Yuan-Zhi Tan . Oxa-helicenes embedding heptagons by stepwise cyclization of [6]helicene unit. Chinese Chemical Letters, 2025, 36(11): 110982-. doi: 10.1016/j.cclet.2025.110982
17. [17]
  Xiaodong Zhang , Bohui Xu , Deshuai Xiao , Xinyuan Zhang , Pifu Gong , Zheshuai Lin . From centrosymmetric CN3H6C6H5SO3 to non-centrosymmetric CN3H6C6H4SO3(OH): Hydroxyl introduced hydrogen bond reconstruction to realize strong second harmonic generation. Chinese Journal of Structural Chemistry, 2025, 44(10): 100707-100707. doi: 10.1016/j.cjsc.2025.100707
18. [18]
  . Cover and Table of Contents for Vol.42 No. 6. Acta Physico-Chimica Sinica, 2026, 42(6): 0-.
19. [19]
  . . University Chemistry, 2026, 41(6): 0-0.
20. [20]
  Pan Liu , Yanming Sun , Alberto J. Fernández-Carrión , Bowen Zhang , Hui Fu , Lunhua He , Xing Ming , Congling Yin , Xiaojun Kuang . Bismuth-based halide double perovskite Cs₂KBiCl₆: Disorder and luminescence. Chinese Chemical Letters, 2024, 35(5): 108641-. doi: 10.1016/j.cclet.2023.108641

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(1453)
HTML views(36)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return