Citation: Shang Hui HU, Xu Fang TIAN, Wen Yi HE, Man KONG, Di An SUN, Qi Cheng FANG. Microbial Transformation of Taxoids and Synthesis of Taxoids ith an Oxetane Ring[J]. Chinese Chemical Letters, ;1998, 9(1): 39-43. shu

Microbial Transformation of Taxoids and Synthesis of Taxoids ith an Oxetane Ring

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

Received Date: 29 September 1997

Fund Project: We thank the State Commission of Education,PRC for financial support.

Microbial transformation of taxoids was investigated:taxoid 2 was transformed into 1β and 14β hydroxylated derivatives 3 and 4; unnatural taxoid 6 was transformed into 1β-hydroxy derivative 7 and 11(15→1) abeotaxane 8. Taxoids with an oxetane ring, 11-13 were synthesized from 1 via chemical reactions.
- Taxoid,
- abeotaxane,
- oxetane ring,
- chemoenzymatic method
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