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Citation: Guo Qing, Li Yanwu, Ren Xuezhuang, Yuan Jianyong. Synthesis of a Novel Intermediate of Lapatinib[J]. Chemistry, ;2017, 80(4): 392-395. shu

Synthesis of a Novel Intermediate of Lapatinib

Pharmacy College, Chongqing Medical University, Chongqing 400016

Corresponding author: Yuan Jianyong, enediyne09@163.com
Received Date: 19 March 2016
Accepted Date: 12 August 2016

Figures(2)

A Schiff base was synthesized from commercially available 5-bromo-2-furaldehyde and 2-(methylsulfonyl)ethaneamine in the nucleophilic additional reaction. A novel intermediate of lapatinib was synthesized from the Schiff base by hydrogenation reduction, amino protection, borylation reaction. The overall yield is 66.32%.
- Lapatinib,
- Organomagnesium complex,
- Synthesis
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