Citation: Guang Rong ZHENG, Wei LU, Jun Chao CAI. Synthetic Study towards Taurospongin A: Wittig Olefination Approach to the Core Structure[J]. Chinese Chemical Letters, ;2001, 12(11): 961-964. shu

Synthetic Study towards Taurospongin A: Wittig Olefination Approach to the Core Structure

Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, Shanghai 200031

Received Date: 2 April 2001

Fund Project: We thank the State Key Laboratory of Drug Research of China for financial support.

An efficient, convergent and enantioselective synthetic approach to the trihydroxy core structure 2 of Taurospongin A 1 is described. The featured step is a classic Wittig coupling reaction between C1-C4 aldehyde segment 4 and C5-C10 phosphate salt segment (5).
- Taurospongin A,
- Wittig olefination,
- enantioselective synthesis
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