引用本文:
刘军, 周仕东. “苯乙酮的制备”实验替代——推荐一个合成化学实验[J]. 大学化学,
2022, 37(12): 211205.
doi:
10.3866/PKU.DXHX202112050
Citation: Jun Liu, Shidong Zhou. Replacing Benzene with Aniline for Synthesis of Acetophenone: A Synthetic Chemistry Experiment[J]. University Chemistry, 2022, 37(12): 211205. doi: 10.3866/PKU.DXHX202112050
Citation: Jun Liu, Shidong Zhou. Replacing Benzene with Aniline for Synthesis of Acetophenone: A Synthetic Chemistry Experiment[J]. University Chemistry, 2022, 37(12): 211205. doi: 10.3866/PKU.DXHX202112050
“苯乙酮的制备”实验替代——推荐一个合成化学实验
摘要:
设计以苯胺为原料，经Friedel-Crafts酰基化反应制备对氨基苯乙酮，替代以苯为原料制备苯乙酮的实验。替代后不仅提高了实验的安全性，而且还能培养学生连续多步骤合成目标产物的实验能力，引导学生思考氨基保护在合成中的应用，有利于对学生进行科学方法和科学思维的训练。
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关键词:
- Friedel-Crafts酰基化反应
- / 苯胺
- / 苯乙酮
English
Replacing Benzene with Aniline for Synthesis of Acetophenone: A Synthetic Chemistry Experiment
Abstract:
An experiment was designed to replace benzene with aniline as the raw material in the preparation of p-aminoacetophenone by Friedel-Crafts acylation. In addition to the safety benefits, this modification challenges the students’ ability to continuously synthesize the target product in multiple steps; encourages the students to think about the application of amino protection during synthesis; promotes the use of scientific methods and thinking.
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Key words:
- Friedel-Crafts acylation
- / Aniline
- / Acetophenone
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