Citation:
Wu Rui, Lu Jiufu, Hao Liang, Zhang Qiang. Molecular Imaging Probes[J]. Chemistry,
;2019, 82(10): 886-892.
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Molecular imaging has been experiencing an unprecedented expansion in recent years in biomedical fields and plays an important role in diagnosis and treatment. It is also an interdisciplinary discipline involving chemistry, medicine, biology, computer science, radiology, and materials science. With the development of molecular imaging, the key factor for molecular imaging is to synthesize smart and efficient imaging probes as well as the need for advanced imaging equipment. Excellent progress has been achieved in molecular imaging probes, and it has been widely applied in research and clinic. In this paper, the progress in main five types of molecular imaging probes, including ultrasound imaging probe, X-ray computed tomography (CT) imaging probe, optical imaging probe, nuclear magnetic resonance imaging (MRI) probe, positron emission tomography (PET) imaging probe were reviewed. The application of the molecular imaging probe was introduced. Finally, the development of molecular imaging in the future was prospected.
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Keywords:
- Molecule imaging,
- Probe
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[1]
W F Lai, A L Rogach, W T Wing. Chem. Soc. Rev., 2017, 46:6379~6419.
- [2]
-
[3]
V Gujrati, A Mishra and V Ntziachristos. Chem. Commun., 2017, 53:4653~4672.
-
[4]
S H Crayton, A K Chen, J F Liu et al. Molecular Imaging//, Comprehensive Biomaterials Ⅱ, Elsevier, 2017, 3:24~46.
-
[5]
Y Y Hong, K Heebeom, K Kwangmeyung et al. Biomaterials, 2017, 132:28~36.
-
[6]
P Parasuraman, K Ajay, K Sundramurthy et al. Acta Biomater., 2016, 41:1~16.
-
[7]
P Arbeille, V Eder, D Casset et al. Ultras. Med. Biol., 2000, 26:201~208.
- [8]
-
[9]
Y Y Wang, X J Liu, G Y Deng et al. J. Mater. Chem., 2017, 5:4221~4232.
-
[10]
-
[11]
Y Li, Y H Chen, M Du et al. ACS Biomater. Sci. Eng., 2018, 4:2716~2728.
- [12]
-
[13]
S Tinkov, R Bekeredjian, G Winter et al. J. Pharm. Sci., 2009, 98:1935~1961.
-
[14]
S Tinkov, R Bekeredjian, G Winter et al. Adv. Drug. Deliv. Rev., 2008, 60:1153~1166.
- [15]
-
[16]
A J Mieszawska, W J M Mulder, Z A Fayad et al. Mol. Pharm., 2013, 10:831~847.
-
[17]
P K Jain, I H Sayed, M A E Sayed. Nano Today, 2007, 2:18~29.
-
[18]
K Sahak, S S Agasti, C Kim et al. Chem. Rev., 2012, 112:2739~2779.
-
[19]
J Hainfeld, D Slatkin, T Focella et al. Brit. J. Radiol., 2006, 79:248~253.
-
[20]
R Popovtzer, A Agrawal, N A Kotov et al. Nano Lett., 2008, 8:4593~4596.
-
[21]
D Kim, S Park, J H Lee et al. J. Am. Chem. Soc., 2007, 129:7661~7665.
-
[22]
M Y Benjamin, F Paul, F FitzGerald et al. Adv. Drug. Deliv. Rev., 2017, 113:201~222.
-
[23]
R Wu, S H Zhang, Q Zhang et al. Sens. Actuat B, 2019, 282:750~755.
- [24]
-
[25]
T Xiong, Z H Zhang, B F Liu et al. Oral. Oncol., 2005, 41:709~715.
-
[26]
M H Chen, Y T Pan, Y C Chen et al. Chem. Sci., 2018, 9:3141~3151.
-
[27]
- [28]
-
[29]
S A Shojaee, A Zandiatashbar, N Koratkar et al. Carbon, 2013, 62:510~513.
-
[30]
S Y Lin, N T Chen, S P Sum et al. Chem. Commun., 2008, 39:4762~4764.
-
[31]
S H Zhang, H B Cui, M Gu et al. Small, 2019, 15:1804662~1804671.
-
[32]
T Ozawa, H Yoshimura, S B Kim et al. Anal. Chem., 2013, 85:590~609.
-
[33]
M Edinger, P Hoffmann, C H Contag et al. Methods, 2003, 31:172~179.
-
[34]
H Caysa, R Jacob, N Müther et al. Photochem. Photobiol. Sci., 2009, 8:52~56.
-
[35]
M K Yu, Y Y Jeong, J Parkl. Angew. Chem. It. Ed., 2008, 47:5362~5365.
-
[36]
Z F Gao, X J Liu, Y Y Wang et al. Dalton Transac., 2016, 45:19519~19528.
-
[37]
S J Liu, B Jia, R R Qiao et al. Mol. Pharm., 2009, 6:1074~1082.
- [38]
-
[39]
X M Lu, C Wang, X Li et al. Bioorg. Med. Chem., 2019, 27:545~551.
-
[40]
H D auwen, V B Clster, C M Deroose et al. Gynecol, 2013, 131:694~700.
-
[41]
M Fularz, P Adamiak, R Czepczynski et al. Ginekol. Pol., 2013, 84:720~725.
-
[42]
M J Song, S H Bae, S W Lee et al. Eur. J. Nucl. Med. Mol. Imag., 2013, 40:865~873.
-
[43]
R Wu, J F Lu, J Song et al. Chin. J. Inorg. Chem., 2019, 35:891~900.
-
[44]
S Richter, M Wuest, C N Bergman. Bioconj. Chem., 2015, 26:201~212.
-
[45]
J Ermert. Biomed. Res. Int., 2014, 81:2973~2978.
-
[46]
W R Sanhal, J H Sakamoto, R Canady. Nat. Nanotechnol., 2008, 3:242~244.
-
[47]
N J Taylor, E Emer, S Preshlock et al. J. Am. Chem. Soc., 2017, 139:8267~8276.
-
[48]
J H Lee, H B Zhou, C S Dence. Bioconju. Chem., 2010, 21:1096~1104.
-
[49]
H L Kim, K. Sachin, H J Jeong. ACS Med. Chem. Lett., 2015, 6:402~407.
-
[50]
S Verhoog, C W Kee, Y Wang. J. Am. Chem. Soc., 2018, 142:1572~1575.
-
[51]
L Q Xiong, B Shen, D Behera et al. Nanoscale, 2013, 5:3253~3256.
-
[52]
M Radović, S V Durić, N Nikolić et al. J. Mater. Chem., 2012, 22:24017~24025.
-
[53]
M Radović, M Mirković, M Perić et al. J. Mater. Chem. B, 2017, 5:8738~8747.
-
[54]
H Honarvar, C Müller, S Cohrs et al. Nucl. Med. Biol., 2017, 45:15~21.
-
[55]
N K Devaraj, E J Keliher, G M Thurber et al. Bioconj. Chem., 2009, 20:397~401.
-
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