Citation: Qing Xuan XU, Li LI, Hao YUE, Zhi Qiang LIU, Ming Quan GUO, Shu Ying LIU. Detection and Characterization of Non-covalent Complex between Lappaconitine and β-Cyclodextrin by Electrospray Ionization Tandem Mass Spectrometry[J]. Chinese Chemical Letters, ;2006, 17(1): 65-68. shu

Detection and Characterization of Non-covalent Complex between Lappaconitine and β-Cyclodextrin by Electrospray Ionization Tandem Mass Spectrometry

Laboratory of New Drug Research and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022

Received Date: 11 May 2005

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 30472134, 20173057), the State Great Basic Research Project of China (No. 2003CCA03100) and the Great Research Project of Chinese Academy of Sciences (No. KGCX2-SW-213-06).

The non-covalent complexes between lappaconitine (LA) and β-cyclodextrin (β-CD) have been detected and characterized by electrospray ionization combined with ion trap tandem mass spectrometry (ESI-MSⁿ). The experimental results showed that only 1:1 non-covalent complex can be formed in different starting molar ratios of LA to β-CD. Furthermore, the diagnostic fragmentation of the β-CD-LA complex, with a significant contribution of covalent fragmentation of LA leaving the N-acetyl anthranoyl (AN) moiety inserted to β-CD, provided the convincing evidence for the formation of non-covalent complex between LA and β-CD and the cite of LA molecule included to cavity of β-CD assigned to AN residue.
- Lappaconitine,
- β-cyclodextrin,
- non-covalent complex,
- ESI-MS,
- CID
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