Citation: Zhenhua Tang, Jiamin Liu, Yihong Fu, Weinan Hu, Zhenchao Wang, Guiping Ouyang. Progress in Antitumor Activity of 3-Substituted Indole Derivatives[J]. Chemistry, ;2021, 84(1): 47-52. shu

Progress in Antitumor Activity of 3-Substituted Indole Derivatives

Zhenhua Tang ¹ ,
Jiamin Liu ¹ ,
Yihong Fu ¹ ,
Weinan Hu ¹ ,
Zhenchao Wang ^{1, 2,,} ,
Guiping Ouyang ^{1, 2, 3,,}

1.
School of Pharmacy, Guizhou University, Guiyang, 550025
2.
State Key Laboratory of Functions and Application of Medicinal Plants, Guizhou Medicinal University, Guiyang, 550014
3.
Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang, 550025

Corresponding author: Zhenchao Wang, wzc.4884@163.com Guiping Ouyang, oygp710@163.com
Received Date: 28 June 2020
Accepted Date: 2 September 2020

Indole is a compound widely found in nature, having a variety of biological activities like antitumor, antioxidant and antibacterial. The introduction of different substituents at the 3-position on the indole ring for structural modification and transformation has always been a drug research hotspot. In this article the related literature in recent years were summarized, and the antitumor activities of 3-substitution indole derivatives with the different heterocycle substituents such as pyrazoles and pyrazolines, diazoles and triazoles, cyclization with 2-position were reviewed in order to provide a theoretical basis for the development of highly active antitumor drugs.
- 3-substitution indole,
- Heterocycle,
- Antitumor activity
1. [1]
  Singh T P, Singh O M. Mini-Rev. Med. Chem., 2018, 18(1): 9~25.
2. [2]
  Dal Molin G Z, Omatsu K, Sood A K, et al. Ther. Adv. Med. Oncol., 2018, 10: 1~13.
3. [3]
  Van Veggel B, Madeira R S J F V, Hashemi S M S, et al. Lung Cancer, 2020, 141: 9~13.
4. [4]
  Dias J N R, Aguiar S I, Pereira D M, et al. Oncotarget, 2018, 9(47): 28586~28598.
5. [5]
  Cheng Y, Cai L, Jiang P, et al. Eur. J. Pharm., 2013, 715(1-3): 219~229.
6. [6]
  Dadashpour S, Emami S. Eur. J. Med. Chem., 2018, 150: 9~29.
7. [7]
  Rosales P F, Bordin G S, Gower A E, et al. Fitoterapia, 2020, 143: 104558.
8. [8]
  Kumar D, Sharma S, Kalra S, et al. Curr. Drug Targets, 2020: 115327.
9. [9]
  Chen F Y, Li X, Zhu H P, et al. Front. Pharmacol., 2020, 11: 280.
10. [10]
  Wan Y, Li Y, Yan C, et al. Eur. J. Med. Chem., 2019, 183: 111691.
11. [11]
  Zhang D T, Wang G T, Zhao G L, et al. Eur. J. Med. Chem., 2011, 46(12): 5868~5877.
12. [12]
  Bhale P S, Bandgar B P, Dongare S B, et al. Phosphorus Sulfur, 2019, 194(8): 843~849.
13. [13]
  Zhang Y L, Qin Y J, Tang D J, et al. ChemMedChem, 2016, 11(13): 1446~1458.
14. [14]
  Chen K, Zhang Y L, Fan J, et al. Eur. J. Med. Chem., 2018, 156: 722~737.
15. [15]
  Shu B, Yu Q, Hu D X, et al. Bioorg. Med. Chem. Lett., 2020, 30(4): 126925.
16. [16]
  Kumar D, Narayanam M K, Chang K H, et al. Chem. Biol. Drug Design, 2011, 77(3): 182~188.
17. [17]
  Tantak M P, Kumar A, Noel B, et al. ChemMedChem, 2013, 8(9): 1468~1474.
18. [18]
  Shirinzadeh H, Ince E, Westwell A D, et al. J. Enzyme Inhib. Med. Chem., 2016, 31(6): 1312~1321.
19. [19]
  Kamath P R, Joseph M M, Abdul Salam A A, et al. J. Biochem. Mol. Toxicol., 2017, 31(11): e21962.
20. [20]
  Netz N, Opatz T. Marine Drugs, 2015, 13(8): 4814~4914.
21. [21]
  Golantsov N E, Festa A A, Karchava A V, et al. Chem. Heter. Compd., 2013, 49(2): 203~225.
22. [22]
  Naaz F, Ahmad F, Lone B A, et al. Bioorg. Chem., 2020, 95: 103519.
23. [23]
  Peng W, Switalska M, Wang L, et al. Eur. J. Med. Chem., 2012, 58: 441~451.
24. [24]
  Chaniyara R, Tala S, Chen C W, et al. J. Med. Chem., 2013, 56(4): 1544~1563.
25. [25]
  Devambatla R K V, Li W, Zaware N, et al. Bioorg. Med. Chem. Lett., 2017, 27(15): 3423~3430.
26. [26]
  Patil S A, Addo J K, Deokar H, et al. Drug Design., 2017, 6(1): 143.
27. [27]
  Jorda R, Reznickova E, Kielczewska U, et al. Eur. J. Med. Chem., 2019, 179: 483~492.
28. [28]
  Spano V, Attanzio A, Cascioferro S, et al. Marine Drugs, 2016, 14(12): 226.
29. [29]
  Lafayette E A, De Almeida S M V, Santos R V C, et al. Eur. J. Med. Chem., 2017, 136: 511~522.
30. [30]
  Gao X, Cen L, Li F, et al. Biochem. Biophys. Res. Commun., 2018, 505(3): 761~767.
31. [31]
  Neochoritis C G, Wang K, Estrada-Ortiz N, et al. Bioorg. Med. Chem. Lett., 2015, 25(24): 5661~5666.
32. [32]
  Cascioferro S, Petri G L, Parrino B, et al. Molecules, 2020, 25(2): 329.
33. [33]
  Zhao B, Zhao C, Hu X, et al. Eur. J. Med. Chem., 2020, 185: 111809.
1. [1]
  Jing WU , Puzhen HUI , Huilin ZHENG , Pingchuan YUAN , Chunfei WANG , Hui WANG , Xiaoxia GU . Synthesis, crystal structures, and antitumor activities of transition metal complexes incorporating a naphthol-aldehyde Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2422-2428. doi: 10.11862/CJIC.20240278
2. [2]
  Huilin ZHENG , Tao WANG , Ruilin GAO , Mengke ZHOU , Xinyue LI , Hui WANG , Xiaoxia GU . Antitumor and antibacterial activities of transition metal complexes incorporating pyridyl salicylaldehyde Schiff base. Chinese Journal of Inorganic Chemistry, 2026, 42(5): 897-905. doi: 10.11862/CJIC.20250358
3. [3]
  Siran Wang , Yinuo Wang , Yilong Zhao , Dazhen Xu . Advances in the Application and Preparation of Rhodanine and Its Derivatives. University Chemistry, 2025, 40(5): 318-327. doi: 10.12461/PKU.DXHX202407033
4. [4]
  Hanxue LIU , Shijie LI , Meng REN , Xuling XUE , Hongke LIU . Design and antitumor properties of dehydroabietic acid functionalized cyclometalated iridium(Ⅲ) complex. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1483-1494. doi: 10.11862/CJIC.20250031
5. [5]
  Hong RAO , Yang HU , Yicong MA , Chunxin LÜ , Wei ZHONG , Lihua DU . Synthesis and in vitro anticancer activity of phenanthroline-functionalized nitrogen heterocyclic carbene homo- and heterobimetallic silver/gold complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2429-2437. doi: 10.11862/CJIC.20240275
6. [6]
  Ping Song , Nan Zhang , Jie Wang , Rui Yan , Zhiqiang Wang , Yingxue Jin . Experimental Teaching Design on Synthesis and Antitumor Activity Study of Cu-Pyropheophorbide-a Methyl Ester. University Chemistry, 2024, 39(6): 278-286. doi: 10.3866/PKU.DXHX202310087
7. [7]
  Xiaotong LU , Pan ZHANG , Zijie ZHAO , Lei HUANG , Hongwei ZUO , Lili LIANG . Antitumor and antibacterial activities of pyridyl Schiff base indium and dysprosium complexes. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1523-1532. doi: 10.11862/CJIC.20250073
8. [8]
  Huiru Sheng , Rui Qi , Chao Shen , Hao Xu , Jiabin Shen , Pengfei Zhang . Green synthesis of pyrrolo[1,2-a]quinoxaline derivatives as antineoplastic agents: a comprehensive chemistry laboratory teaching exploration. University Chemistry, 2026, 41(7): 266-273. doi: 10.12461/PKU.DXHX202505015
9. [9]
  Chi Li , Jichao Wan , Qiyu Long , Hui Lv , Ying Xiong . N-Heterocyclic Carbene (NHC)-Catalyzed Amidation of Aldehydes with Nitroso Compounds. University Chemistry, 2024, 39(5): 388-395. doi: 10.3866/PKU.DXHX202312016
10. [10]
  Jiahao Zeng , Hui Chao . 诱导程序性细胞死亡的金属抗肿瘤药物研究. University Chemistry, 2025, 40(6): 145-159. doi: 10.12461/PKU.DXHX202406019
11. [11]
  Jian Li , Yu Zhang , Rongrong Yan , Kaiyuan Sun , Xiaoqing Liu , Zishang Liang , Yinan Jiao , Hui Bu , Xin Chen , Jinjin Zhao , Jianlin Shi . Highly Efficient, Targeted, and Traceable Perovskite Nanocrystals for Photoelectrocatalytic Oncotherapy. Acta Physico-Chimica Sinica, 2025, 41(5): 100042-0. doi: 10.1016/j.actphy.2024.100042
12. [12]
  Yuyao Chen , Qirui Zou , Bowen Liu , Fuyun Li , Ao Zhang , Xiuwei Fan . NBO分析在研究取代芳烃亲电取代反应区域选择性和活性中的应用. University Chemistry, 2026, 41(9): 442-448. doi: 10.12461/PKU.DXHX202509012
13. [13]
  Jianjun LI , Mingjie REN , Lili ZHANG , Lingling ZENG , Huiling WANG , Xiangwu MENG . UV-assisted degradation of tetracycline hydrochloride by MnFe₂O₄@activated carbon activated persulfate. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1869-1880. doi: 10.11862/CJIC.20240187
14. [14]
  Jiahong WANG , Zekun XU , Tianjiao LU , Jinming HUANG . Performance of N, Mn doped semi-coke activated carbon catalyzed ozone oxidation for the degradation of tetracycline hydrochloride in water. Chinese Journal of Inorganic Chemistry, 2025, 41(12): 2549-2560. doi: 10.11862/CJIC.20250120
15. [15]
  Yang Li , Yuxuan Zhang , Yuhai Tang , Lijuan Wang . Iodide anion-catalyzed green synthesis of m-cresol. University Chemistry, 2026, 41(7): 326-333. doi: 10.12461/PKU.DXHX202506054
16. [16]
  Jiahui YU , Jixian DONG , Yutong ZHAO , Fuping ZHAO , Bo GE , Xipeng PU , Dafeng ZHANG . The morphology control and full-spectrum photodegradation tetracycline performance of microwave-hydrothermal synthesized BiVO₄:Yb³⁺,Er³⁺ photocatalyst. Journal of Fuel Chemistry and Technology, 2025, 53(3): 348-359. doi: 10.1016/S1872-5813(24)60514-1
17. [17]
  Rui LIU , Xinjun ZHOU , Tao WANG . Photocatalytic degradation performance of tetracycline by MOF-74-Mn/g-C₃N₄ Z-type heterojunction. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1796-1804. doi: 10.11862/CJIC.20250033
18. [18]
  Haitao Wang , Lianglang Yu , Jizhou Jiang , Arramel , Jing Zou . S-Doping of the N-Sites of g-C₃N₄ to Enhance Photocatalytic H₂ Evolution Activity. Acta Physico-Chimica Sinica, 2024, 40(5): 2305047-0. doi: 10.3866/PKU.WHXB202305047
19. [19]
  Yuexiang Liu , Xiangqiao Yang , Tong Lin , Guantian Yang , Xiaoyong Xu , Bubing Zeng , Zhong Li , Weiping Zhu , Xuhong Qian . Efficient continuous synthesis of 2-[3-(trifluoromethyl)phenyl]malonic acid, a key intermediate of Triflumezopyrim, coupling with esterification-condensation-hydrolysis. Chinese Chemical Letters, 2025, 36(1): 109747-. doi: 10.1016/j.cclet.2024.109747
20. [20]
  Haitang WANG , Yanni LING , Xiaqing MA , Yuxin CHEN , Rui ZHANG , Keyi WANG , Ying ZHANG , Wenmin WANG . Construction, crystal structures, and biological activities of two Ln^Ⅲ₃ complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1474-1482. doi: 10.11862/CJIC.20240188

Get Citation

PDF

XML

Metrics

PDF Downloads(47)
Abstract views(3796)
HTML views(1051)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142