Citation: ZHANG Jing-Yi, ZHONG Han-Yu, SHI Guo-Bing. Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae[J]. Chinese Journal of Structural Chemistry, ;2014, 33(6): 876-880. shu

Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae

a.
a. Department of Pharmacy, General Hospital of Shenyang Military Command, Shenyang 110016, China;
b.
b. Department of Pharmacy, First Affiliated Hospital, China Medical University, Shenyang 110001, China

Corresponding author: SHI Guo-Bing,
Received Date: 29 November 2013
Available Online: 15 May 2014

Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, one novel cyclopropylamide analogue of combretastatin-A4 (CA-4), has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P2₁/c, with a=15.0263(3), b=7.6574(2), c=19.4117(4)Å, β=111.9010(10)°, V=2072.36(8)Å³, Z=4, C₂₂H₂₄NO₆, M_r=398.42, D_c=1.277 Mg/cm³, F(000)=844, λ(MoKα)=1.54178Å, μ=0.770 mm^-1, R=0.0546 and wR=0.1889 for 3319 observed reflections (I>2σ(I)). Meanwhile, the compound revealed potential antiproliferative activities in several cancer cells in vitro.
- 3,4,5-trimethoxyphenyl,
- synthesis,
- crystal structure,
- antiproliferative activities
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