Citation: Qing PENG, Fan Qi QU, Yi XIA, Jie Hua ZHOU, Qiong You WU, Ling PENG. Synthesis of Photoactivatable Phospholipidic Probes[J]. Chinese Chemical Letters, ;2005, 16(3): 349-352. shu

Synthesis of Photoactivatable Phospholipidic Probes

Qing PENG ^1, ,
Fan Qi QU ¹ ,
Yi XIA ¹ ,
Jie Hua ZHOU ¹ ,
Qiong You WU ¹ ,
Ling PENG ^1,2

1.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072;
2.
AFMB CNRS UMR 6098, Université Aix-Marseille, 163, Avenue de Luminy, 13288 Marseille, France

Received Date: 8 March 2004

Fund Project: We thank Professor Andre Samat for giving us access to the irradiation equipment, Dr. Arnault Heynderickx and Mr. Daniel Compese for their help with the irradiation experiments, and Dr. Jessica Blanc for revising the English manuscript. Financial support from the National Key Project for Basic Research 2003CB114400, the Hi-Tech Research and Development Program of China No. 2003AA2Z3506, Wuhan University and the CNRS is gratefully acknowledged.

We synthesized and characterized photoactivatable phospholipidic probes 1-3. These probes have the perfluorinated aryl azide function at the polar head of phospholipid. They are stable in dark and become highly reactive upon photoirradiation. The preliminary results suggest that they are promising tools to study the topology of membrane proteins and protein-lipid interactions using photolabeling approach.
- Photoactivatable phospholipidic probes,
- photolabeling,
- photolabeling probe,
- proteinlipid interactions,
- membrane protein topology.
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