引用本文:
潘勇, 王德才, 江建. (4R,5R)-4,5-双(氨甲基)-1,3-二氧戊环类化合物的合成[J]. 应用化学,
2009, 26(2): 237-239.
Citation: PAN Yong, WANG De-Cai, JIANG Jian. Synthesis of (4R,5R)-4,5-Bis(aminomethyl)-1,3-dioxolane[J]. Chinese Journal of Applied Chemistry, 2009, 26(2): 237-239.
Citation: PAN Yong, WANG De-Cai, JIANG Jian. Synthesis of (4R,5R)-4,5-Bis(aminomethyl)-1,3-dioxolane[J]. Chinese Journal of Applied Chemistry, 2009, 26(2): 237-239.
(4R,5R)-4,5-双(氨甲基)-1,3-二氧戊环类化合物的合成
English
Synthesis of (4R,5R)-4,5-Bis(aminomethyl)-1,3-dioxolane
Abstract:
We developed a simple and efficient three-step method,that is,aldol condensation,aminolysis with gaseous ammonia and reduction by LiAlH4,to synthesize(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane.The average yield were 52.1%,higher than 22.4% reported in the literature.Five new compounds were synthesized with the new method,and their structures were confirmed by MS-ESI,1H NMR and elemental analysis.
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Key words:
- aldol condensation
- / aminolysis
- / amide reduction
- / synthesis
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