引用本文:
高中军, 刘广军, 尹汉东. 有机锡(Ⅳ)配合物{[(n-C4H9)2Sn(0.5·O2CCH2C12H8N)(0.5·C2H5O)]2O}2·(C12H8NH)的合成、结构和抑瘤活性[J]. 应用化学,
2009, 26(2): 140-143.
Citation: GAO Zhong-Jun, LIU Guang-Jun, YIN Han-Dong. Synthesis,Crystal Structure and Antitumor Activity of Organotin(Ⅳ) Complex{[(n-C4H9)2Sn(0.5·O2CCH2C12H8N)(0.5·C2H5O)]2O}2·(C12H8NH)[J]. Chinese Journal of Applied Chemistry, 2009, 26(2): 140-143.
Citation: GAO Zhong-Jun, LIU Guang-Jun, YIN Han-Dong. Synthesis,Crystal Structure and Antitumor Activity of Organotin(Ⅳ) Complex{[(n-C4H9)2Sn(0.5·O2CCH2C12H8N)(0.5·C2H5O)]2O}2·(C12H8NH)[J]. Chinese Journal of Applied Chemistry, 2009, 26(2): 140-143.
有机锡(Ⅳ)配合物{[(n-C4H9)2Sn(0.5·O2CCH2C12H8N)(0.5·C2H5O)]2O}2·(C12H8NH)的合成、结构和抑瘤活性
摘要:
由9-咔唑乙酸和二丁基氧化锡反应制得了新配合物{[(n-C4H9)2Sn(0.5·O2CCH2C12H8N)(0.5·C2H5O)]2O}2·(C12H8NH)。通过元素分析、红外光谱和核磁共振氢谱对其结构进行了表征,用X射线单晶衍射测定了配合物的晶体和分子结构。该配合物晶体属于单斜晶系,C2/c空间群,晶胞参数a=2.797 5(13)nm,b=2.153 4(10)nm,c=1.515 4(7)nm,β=118.759(6)°,V=8.003(7)nm3,Z=4,μ=1.285 mm-1,Dc=1.386 g/cm3,F(000)=3 408,R=0.0571,wR=0.136 2,GOF=1.005。结构测定表明,它具有以Sn2O2四元环为中心,中心对称的二聚体结构。内、外环Sn原子均为五配位的畸变三角双锥构型。生物活性测试结果表明,该配合物对体外培养的乳腺癌细胞株MCF-7和结肠癌细胞株WiDr有较好的抑制活性。
English
Synthesis,Crystal Structure and Antitumor Activity of Organotin(Ⅳ) Complex{[(n-C4H9)2Sn(0.5·O2CCH2C12H8N)(0.5·C2H5O)]2O}2·(C12H8NH)
Abstract:
Organotin(Ⅳ) complex {[(n-C4H9)2Sn(0.5·O2CCH2C12H8N)(0.5·C2H5O)]2O}2·(C12H8NH) was synthesized by the reaction of n-dibutyltin oxide with(9-carbazoly)-acetic acid.The complex was characterized by elemental analysis,IR and 1H NMR.The crystal structure was determined by X-ray single crystal diffraction.The crystal belongs to monoclinic,with space group C2/c with a=2.797 5(13) nm,b=2.153 4(10) nm,c=1.515 4(7) nm,β=118.759(6)°,V=8.003(7) nm3,Z=4,μ=1.285 mm-1,Dc=1.386 g/cm3,F(000)=3 408,R=0.057 1,wR=0.136 2,GOF=1.005.The complex is a centrosymmetric structure mode with a four-member central endo-cyclic Sn2O2 unit in which two bridged oxygen atoms both connect with an exo-cyclic tin atom.The endo-cyclic tin atoms and the exo-cyclic tin atoms are all five-coordination and have a coordination geometry of a distorted trigonal bipyramid.This complex was tested in vitro against human tumour cell lines,MCF-7 and WiDr,and displayed high activity.
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Key words:
- organotin(Ⅳ) complex
- / (carbazoly)-acetic acid
- / synthesis
- / crystal structure
- / antitumor activity
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