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Citation: ZHANG Hong-Fang, ZHANG Ya, YANG Rui-Li, ZHENG Jian-Bin. Electroreduction Behavior of Propafenone and Its Application[J]. Chinese Journal of Applied Chemistry, ;2009, 26(1): 104-107. shu

Electroreduction Behavior of Propafenone and Its Application

1.
Institute of Analytical Science/Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry, Northwest University, Xi'an 710069

Corresponding author: ZHENG Jian-Bin,
Received Date: 27 February 2008
Available Online: 1 July 2008

The electroreduction behavior of antiarrhythmic drug propafenone at Hg electrode was studied by means of linear sweep polarography,and a new determination method of propafenone in factual samples was developed.In solution with pH11.6,only one reduction peak was observed in the linear sweep polarogram and the mechanism of the peak was studied.In the solution with pH11.6,two reduction waves(P₁,P₂) can be observed in the polarogram.P1 was proved to be a catalytic hydrogen wave and P₂ was attributed to the reduction of propafenone itself.In a Britton-Robinson buffer(pH=12.3),a linear relationship can be established between the second order polarographic wave current of P₁ and the concentration of propafenone in a range of 9.6×10^-8 to 4.0×10^-6 mol/L with a detection limit of 5×10^-8 mol/L.The RSD of 6 repeated measurements of 1.0×10^-6 mol/L propafenone was 1.2%.The second order polarography was utilized to determine the content of propafenone in tablets and spiked serum.The determination results of propafenone in tablets by the second order derivative polarography were in agreement with the results obtained by UV spectrophotometry,and the recovery of propafenone in spiked serum was between in 98.6% to 102%.
- electrochemical behavior,
- polarography,
- propafenone,
- catalytic hydrogen wave
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