Citation: Zhang Suge, Sun Hongxia, Tang Yalin. Research Progress in the Probes Targeting DNA G-quadruplex[J]. Chemistry, ;2016, 79(5): 387-394. shu

Research Progress in the Probes Targeting DNA G-quadruplex

1.
Institute of Chemistry, Chinese of Academy of Sciences, Beijing 100190

Corresponding author: Sun Hongxia, Tang Yalin,
Received Date: 30 November 2015
Available Online: 28 December 2015
Fund Project:

G-quadruplexes are non-canonical secondary DNA/RNA structure formed by guanine-rich oligonucleotide sequences, which widely exist in eukaryotic genomes, such as telomeric DNA, rDNA, and promoter regions of oncogenes. G-quadruplex structure may play a pivotal role in the control of a variety of cellar processes including telomere maintenance, replication, transcription, and translation. Detection of the quadruplex structures using the probes with high specificity and sensitivity will help us to explore the distribution, function, and mechanism of G-quadruplexes in human cells, and may also provide new diagnostic and therapeutic approaches of cancer via targeting G-quadruplex. In the last two decades, various targeting G-quadruplex probes which have high selectivity and sensitivity have been designed, and these probes have been used to recognize different G-quadruplex topologies in solutions. A few probes have also been applied to recognize G-quadruplex in vivo. This article reviews the typical probes targeting G-quadruplexes as well as their application in detection G-quadruplexes in chromosome and cell level. Authors hope this paper can provide a certain reference for design of G-quadruplex-targeting probes and further realization of G-quadruplex detection in living cells.
- G-quadruplex,
- Small molecule ligands,
- Fluorescent probe,
- Chromosome,
- Living cells
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