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1,3,4-噻二唑衍生物合成及其生物活性研究进展

刘玮炜 ,  刘秀坚 ,  殷龙 ,  程峰昌

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引用本文: 刘玮炜, 刘秀坚, 殷龙, 程峰昌. 1,3,4-噻二唑衍生物合成及其生物活性研究进展[J]. 化学通报, 2016, 79(10): 929-935,941. shu
Citation:  Liu Weiwei, Liu Xiujian, Yin long, Cheng Fengchang. Progress in Syntheses and Biological Activities of 1,3,4-Thiadiazole Derivatives[J]. Chemistry, 2016, 79(10): 929-935,941. shu

1,3,4-噻二唑衍生物合成及其生物活性研究进展

  • 1.

    1. 淮海工学院化学工程学院 连云港 222005;

  • 2.

    2. 江苏省海洋药物活性分子筛选重点实验室 连云港 222005;

  • 3.

    3. 江苏省海洋资源开发研究院 连云港 222005;

  • 4.

    4. 中国矿业大学化工学院 徐州 221116

  • 基金项目:

    江苏高校优势学科建设工程资助项目、江苏省自然科学基金项目（BK20151281) 

    江苏省海洋生物技术重点实验室研究基金项目（HS2014007) 

    连云港市科技攻关项目（CG1415) 

    海洋公益性行业科研专项经费项目（201505023）资助 

摘要: 1，3，4-噻二唑是含有N、S杂原子的五元杂环化合物，具有多种生物活性。目前，1，3，4-噻二唑及其衍生物广泛用于生物、医药等领域，尤其在抗菌、抗肿瘤、抗癌等方面的研究已取得重大突破。由于1，3，4-噻二唑结构的特殊性以及优越的生物活性，对其进行研究有重要意义。本文主要概述了近年来1，3，4-噻二唑衍生物的几种合成方法以及其在抗菌、抗肿瘤、抗癌方面的研究进展。

English

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  • 收稿日期:  2016-01-11
  • 网络出版日期:  2016-05-28
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