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Citation: Zhang Lin, Xie Rugang. Synthesis and Reduction of Deuterated Acetophenone-d₈[J]. Chinese Journal of Applied Chemistry, ;1999, 16(1): 115-116. shu

Synthesis and Reduction of Deuterated Acetophenone-d₈

Zhang Lin ^a ,
Xie Rugang ^b

1.
a Institute of Nuclear Physics and Chemistry, Chinese Academy of Engineering Physics, Chengdu 610003;
2.
b Department of Chemistry, Sichuan University, Chengdu

Received Date: 23 July 1998
Available Online: 17 November 1998
Fund Project: 国家高技术基金资助项目(8634163) (8634163)

Deuterated acetophenone-d₈(C₆D₅-COCD₃) was prepared from perdeutero-benzene (C₆D₆)and perdeutero-acetic acid in high yield and high deuterium isotopic content(about 86% and 99.3% respectively). C₆D₅-COCD₃ was then reduced with nickel-aluminum (Ni-Al) alloy in 12%~18% NaOD-D₂O solution to give corresponding deuterated α-phenylethanol-d₁₀(C₆D₅-CDODCD₃), the yield and deuterium isotopic content were 85.2% and 99.2%.
- deuterated acetophenone-d₈,
- synthesis,
- nickel-aluminum alloy,
- reduction,
- deuterated α-phenylethanol-d₁₀
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Synthesis and Reduction of Deuterated Acetophenone-d₈