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Citation: LIU Jing-Fu, WANG Xiao-Hong, SUN Zhen-Gang, LI Heng-Da. Bioactivity of Organic and Organometallic Substituted Polyoxometalates[J]. Chinese Journal of Applied Chemistry, ;2001, 18(5): 357-359. shu

Bioactivity of Organic and Organometallic Substituted Polyoxometalates

1.
Department of Chemistry, Northeast Normal University, Changchun 130024

Received Date: 5 January 2001
Available Online: 1 March 2001
Fund Project: 国家自然科学基金资助项目(39970842) (39970842)

A number of organotin, cyclopentadienyltitanium, cyclopentadienylzirconium and organophosphoryl substituted polyoxometalates are reported in relation of their antitumor activity against SSMC-7721 and Hela human tumor cells. The cyclopentadienyltitanium polyoxometalates showed higher activity than other compounds with the same polyanions. CoW₁₁CpTi was found to have higher antitumor activity and low toxicity as showed in vivo tests. It is also observed that the order of the antitumor activity of complexes is in relation with the order of the redox behavior of the polyanions.
- organometalate,
- polyoxometalate,
- antitumor activity
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