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Citation: LI Nai-Xuan, XIAO Ru-Ting, DONG Ying, GAO Su-Hua, YANG Jun-Jie. The Resolution of Propranolol Enantiomers by HPLC with Two-Phase Discrimination[J]. Chinese Journal of Applied Chemistry, ;2003, 20(11): 1084-1087. shu

The Resolution of Propranolol Enantiomers by HPLC with Two-Phase Discrimination

1.
Department of Biology and Chemical Engineering, Tianjin Institute of Technology, Tianjin 300191

Corresponding author: LI Nai-Xuan,
Received Date: 18 February 2003
Available Online: 28 July 2003
Fund Project: 天津市教委科技发展基金资助项目(0120510) (0120510)

The resolution of propranolol enantiomers has been sucessfully carried out by HPLC using two phase discrimination:γ-amino propyl silica gel coated with 15%(mass fraction) of cellulose tribenzoate(CTB) as chiral stationary phase and hexane-alcohol(V:V=85:15) soltuion containing 0.40 mmol/L N-benzyloxycarbonyl-S-phenyl-L-cysteine(BPC) as chiral mobile phase. The chromatiographic method with flow rate of 0.3 mL/min and UV detection at 254 nm gave a separation selectivity of 1.30 and a separation degree of 1.56. The discrimination of CTB to propranolol enantiomers was apparently improved by the presence of BPC. The resolution mechanism of the two-phases discrimination has been discussed based on the thermodynamic parameters obtained.
- propranolol,
- resolution,
- two phases discrimination,
- high performance liquid chromatography
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