引用本文:
刘守信, 冯霄, 甄晓丽, 田霞. 秋水仙胺半合成新方法[J]. 应用化学,
2005, 22(5): 569-571.
Citation: LIU Shou-Xin, FENG Xiao, ZHEN Xiao-Li, TIAN Xia. A Novel Semi-synthesis Method for Demecolcine[J]. Chinese Journal of Applied Chemistry, 2005, 22(5): 569-571.
Citation: LIU Shou-Xin, FENG Xiao, ZHEN Xiao-Li, TIAN Xia. A Novel Semi-synthesis Method for Demecolcine[J]. Chinese Journal of Applied Chemistry, 2005, 22(5): 569-571.
English
A Novel Semi-synthesis Method for Demecolcine
Abstract:
Demecolcine was synthesized from colchicine in two steps.The methylation of colchicine with iodomethane was carried out in a THF solution of potassium t-butoxide at -20℃ for 4 h.The product was isolated on a silica gel flash column with a yield of over 78%.N-Methylcolchicine was then hydrolyzed in i-propanol and aqueous solution of sodium hydroxide under refluxing temperature to give demecolcine.The overall yield was 69%.The structures of the two products were confirmed by IR and 1H NMR.
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Key words:
- demecolcine
- / colchicine
- / semi-synthesis
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