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Citation: ZHAI Mu-Heng, SHANG Yong-Jia, DU Bao-Hui, HU Ji-Ping, ZHANG De-Xing, SHEN Liang-Jun. Synthesis of Bifunctional Poly (ethylene oxide) with Targeting and Contrast-medium Groups[J]. Chinese Journal of Applied Chemistry, ;2005, 22(5): 517-520. shu

Synthesis of Bifunctional Poly (ethylene oxide) with Targeting and Contrast-medium Groups

1.
College of Chemisty and Materials Science, Anhui Normal University, Wuhu 241000

Corresponding author: ZHAI Mu-Heng,
Received Date: 16 August 2004
Available Online: 3 December 2004
Fund Project: 安徽省教委自然科学基金(2001kj094)资助 (2001kj094)

2-Sulfanilylpyrimidine (sulfadiazine) sodium was used to initiate the ring-opening polymerization of ethylene oxide to form sodium sulfadiazine poly (ethylene oxide)(PEO) inhomogeneously,and the polymerization was terminated with 3,5-di-(N-acetamino)-2,4,6-triiodobenzoyl chloride to form a bifunctional PEO with a targeting and a contrast-medium group.The reaction time was about 96 h at 80℃.The yield was 87%~90%.The PEO was characterized with IR,¹H NMR,and UV.The PEO molecular weights were determined with VPO and GPC.The products with different molecular weights were obtained with different amounts of initiator in the reaction.The molecular weight distribution was narrower when a less amount of initiator was used.The molecular weight range of PEO was from 2 692 to 11 040,and the molecular weight distribution was from 1.195 to 1.704.The content ranges of sulfadiazine group and 3,5-di (N-acetamino)-2,4,6-(triiodobenzoyl) acyl group in PEO with different molecular weights were 2.13%~8.98% and 5.25%~21.72%,respectively.At room temperature,the products dissolve easily in water,DMSO,DMF,THF,chloroform,ethanol,pyridine,propanone,benzene,toluene,etc.
- di (N-acetamino)-triiodobenzoyl acid,
- sulfanilylpyrimidine,
- targeting,
- contrast agent,
- poly (ethylene oxide),
- ring-opening polymerization
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