引用本文:
李德江, 傅和青, 葛正鸿. 2-芳基-3-N-丙酰基-5-(2-溴-4-氟苯基)-1,3,4-噁二唑啉类衍生物的合成及抗菌活性[J]. 应用化学,
2006, 23(8): 936-938.
Citation: LI De-Jiang, FU He-Qing, GE Zheng-Hong. Synthesis and Antibacterial Activities of 2-Aryl-3-N-Propanoyl-5-(2-Bromo-4-Fluorophenyl)1,3,4-Oxadiazoline Derivatives[J]. Chinese Journal of Applied Chemistry, 2006, 23(8): 936-938.
Citation: LI De-Jiang, FU He-Qing, GE Zheng-Hong. Synthesis and Antibacterial Activities of 2-Aryl-3-N-Propanoyl-5-(2-Bromo-4-Fluorophenyl)1,3,4-Oxadiazoline Derivatives[J]. Chinese Journal of Applied Chemistry, 2006, 23(8): 936-938.
2-芳基-3-N-丙酰基-5-(2-溴-4-氟苯基)-1,3,4-噁二唑啉类衍生物的合成及抗菌活性
English
Synthesis and Antibacterial Activities of 2-Aryl-3-N-Propanoyl-5-(2-Bromo-4-Fluorophenyl)1,3,4-Oxadiazoline Derivatives
Abstract:
Condensation of 2-bromo-4-fluorobenzoyl hydrazine(1) with aromatic aldehydes produced corresponding hydrazones(2a~2i).Cyclization of 2a~2i with propanoic anhydide gave the title compounds 3a~3i in good yields of 79.3%~85.5%.Their structures were characterized by means of elemental analysis,IR,1H NMR and MS spectra.The preliminary antibacterial tests showed that most of them had good antibacterial activities.
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