引用本文:
易兵, 谢治民, 党立敏. (3S,4S)-N-苄基-3,4-二羟基氢化吡咯合成方法改进[J]. 应用化学,
2007, 24(2): 223-225.
Citation: YI Bing, XIE Zhi-Ming, DANG Li-Min. Improvement on Synthesis of (3S,4S)-N-Benzyl-3,4-dihydroxy Pyrrolidine[J]. Chinese Journal of Applied Chemistry, 2007, 24(2): 223-225.
Citation: YI Bing, XIE Zhi-Ming, DANG Li-Min. Improvement on Synthesis of (3S,4S)-N-Benzyl-3,4-dihydroxy Pyrrolidine[J]. Chinese Journal of Applied Chemistry, 2007, 24(2): 223-225.
(3S,4S)-N-苄基-3,4-二羟基氢化吡咯合成方法改进
摘要:
采用NaBH4/I2还原体系,在THF溶剂中,对(3S,4S)-N-苄基-3,4-二羟基氢化吡咯的合成方法进行了改进,着重探讨了原料配比,反应时间和还原剂类型等因素对产品收率的影响。在优化的反应条件下,底物、NaBH4和I2的摩尔比为1:5:1.67,回流下反应时间6 h,产品收率达70%。通过1H NMR、13C NMR等测试技术进行了表征,结果与目标化合物一致。与传统的合成方法相比,该法具有相对经济,操作简便,可大量制备的特点。
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关键词:
- (3S,4S)-N-苄基二羟基氢化吡咯
- / NaBH4/I2
- / 合成
English
Improvement on Synthesis of (3S,4S)-N-Benzyl-3,4-dihydroxy Pyrrolidine
Abstract:
(3S,4S)-N-benzyl-3,4-dihydroxy pyrrolidine was synthesized using NaBH4/I2 as the reducing agent in THF.The effect of the molar ratio of the starting materials,the reaction time,and the type of reducting agents were explored.Under the optimum condition,i.e.,the molar ratio of substrate to NaBH4 and I2 was 1:5:1.67,and the refluxing reaction time was 6 h,the yield was up to 70%.The product was charac-terized by 1H and 13C NMR spectroscopy,and all the results were consistent with the compounds synthesized. Compared with the conventional synthetic method,the method has such advantages as inexpensive reagents, simple operation,and easy scaling up.
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Key words:
- (3S,4S)-N-benzyldihydroxy pyrrolidine
- / NaBH4/I2
- / synthesis
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