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Citation: YANG Ming, WANG Wei-Guo, LI Pei-Hua, SHEN Shu-Bao. Microwave Assisted Cleavage of Thymopentin Peptide Resin[J]. Chinese Journal of Applied Chemistry, ;2008, 25(1): 116-118. shu

Microwave Assisted Cleavage of Thymopentin Peptide Resin

1.
College of Life Science and Pharmacy Engineering, Nanjing University of Technology, Nanjing 210009

Corresponding author: SHEN Shu-Bao,
Received Date: 5 February 2007
Available Online: 8 April 2007
Fund Project: 国家自然科学基金资助项目(20376034) (20376034)十一五国家"八六三"(20060102Z2009) (20060102Z2009)江苏省自然科学基金资助项目(BK2006181) (BK2006181)南京工业大学2005博士生创新基金(BSCX200513) (BSCX200513)

Thymopentin resin was cleaved under microwave irradiation with an American Mas 5 microwave reactor.The effects of cleavage reagents,reaction time and reaction temperature on TP5's yield,were studied with HPLC.The mechanism of TPS cleaved from thymopentin resin under microwave irradiation was discussed.The product was characterized by MS and ¹H NMR.The results indicate that TP5's yield reached up to 93.2% at 50℃ with V(TFA):V(H₂O):V(TIS)=95:2.5:2.5 as cleavage reagent under microwave irradiation for five minutes.Compared with the results of conventional method,the cleavage reaction rate and yield of TP5 were increased by 24 times and 21.8%,respectively,while the side reaction and the cost of peptide preparation were reduced.
- microwave,
- cleavage,
- thymopentin,
- peptide resin
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