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Citation: WANG Jun, XIONG Da-Zhen, ZHANG Zhao-Hong, ZHANG Xiang-Dong, LIU Bin, ZHANG Han-Yu, SUN Wei, LI Rong-He. Damage of DNA under Irradiation of High-frequency Ultrasound in the Presence of Hematoporphyrin[J]. Chinese Journal of Applied Chemistry, ;2008, 25(1): 22-26. shu

Damage of DNA under Irradiation of High-frequency Ultrasound in the Presence of Hematoporphyrin

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a Chemistry Department, Liaoning University, Shenyang 110036;
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b Department of Environmental Science, Liaoning University, Shenyang 110036;
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c Pharmaceutical Department, Liaoning University, Shenyang 110036

Corresponding author: WANG Jun,
Received Date: 3 February 2007
Available Online: 9 May 2007
Fund Project: 国家自然科学基金(20371023) (20371023)辽宁省教育厅自然科学基金(2004C018)资助项目 (2004C018)

In this paper,the damage of deoxyribonucleic acid(DNA) under the action of photosensitive compound,hematoporphyrin(HP),activated by ultrasonic irradiation has been investigated by means of UV-Vis and fluorescence(FL) spectra.Under the cooperative action of ultrasonic irradiation and HP,the UV-Vis absorbence of the DNA solution showed obvious hyperchromic effect,while the fluorescence intensity of the DNA-EB solution exhibited evident quenching phenomenon.The influence of ultrasonic irradiation time,HP concentration and solution acidity on the damage of the DNA under ultrasonic irradiation in the presence of HP was also studied.The results showed that,under certain conditions,the damage of the DNA would be enhanced with the increase of ultrasonic irradiation time and HP concentration.However,the influence of solution acidity on the damage of the DNA was more complicated.In weak acidic or neutral solutions,the damage of the DNA was obvious,but the trend decreased for basic solutions.In addition,the HP concentration also decreased,which indicated that the HP was destroyed,too.The possible mechanism on the damage of the DNA under ultrasonic irradiation in the presence of HP was also discussed,which explained such damage of the DNA by the theories of sonoluminescence and "hot spot".These results may provide some guidances for the sonodynamic treatment(SDT) of various cancers in clinic in the future.
- ultrasound,
- hematoporphyrin(HP),
- damage,
- deoxyribonucleic acid(DNA)
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