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Citation: SHI Wen-Bing. Flow-injection Chemiluminescence Analysis of Dioxopromethazine Hydrochloride with Nanometer Microreactor[J]. Chinese Journal of Applied Chemistry, ;2008, 25(4): 441-444. shu

Flow-injection Chemiluminescence Analysis of Dioxopromethazine Hydrochloride with Nanometer Microreactor

SHI Wen-Bing ^,

1.
Department of Chemistry and Environment Science, Changjiang Normal College, Chongqing 408003

Corresponding author: SHI Wen-Bing,
Received Date: 9 April 2007
Available Online: 15 June 2007
Fund Project: 重庆市教委资助项目(KJ061306) (KJ061306)

Under acidic condition,the nitrogen in dioxopromethazine hydrochloride was easily protonated to form ion-complex with negative ion AuCl₄^-,which was extacted and carried by dichloromethane.The ion-complex entered a reversed micella of cetyltrimethylammonium chlorine containing luminol,and the dissociated AuCl₄^- reacted with luminol and produced an analytical chemiluminescnece signal.Under the optimum conditions,i.e.,the concentrations of hydrochloric acid,AuCl₄^-,luminol and sodium carbonate were 0.05 mol/L,20 mg/L,0.4×10^-4 mol/L and 0.3 mol/L (pH=11.5),respectively,the R([H₂O]/[CTAC]) value was 11,the flow rate (per tube) was 3.6 mL/min,the inner diameter (i.d.) of PTFE tubing was 0.8 mm,the sampling volume was 120 μL,the distance between e and injection valve was 8 cm,a glass coil (120 mm,2 mm i.d.) was used as the flow cell,the photomultiplier tube was operated at -650 V,the extraction solvent was dichloromethane,the linear range was 0.001 to 20 mg/L and the limit of detection was 0.06 μg/L with a relative standard deviation (n=11) of ca.1.4% for 1.0 mg/L dioxopromethazine hydrochloride.The method has been applied to the determination of the drug in tablets and biological fluids successfully.
- nanometer microreactor,
- dioxopromethazine hydrochioride,
- chemiluminescence
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