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Citation: GUO Qiao-Xia, SHEN Bao-Jian, TAKAHASHI Tamotsu. MoCl₅-Mediated Aromatic C-H Bond Activation and in situ C-C Bond Coupling Reaction[J]. Chinese Journal of Applied Chemistry, ;2008, 25(9): 1073-1077. shu

MoCl₅-Mediated Aromatic C-H Bond Activation and in situ C-C Bond Coupling Reaction

1.
a Department of Applied Chemistry, State Key Laboratory of Heavy Oil Processing, Faculty of Chemical Science and Engineering, China University of Petroleum, Beijing 102249;
2.
b Catalysis Research Center, and Graduate School of Pharmaceutical Sciences, Hokkaido University, and SORST, Japan Science and Technology Corporation(JST), Sapporo 001-0021

Corresponding author: GUO Qiao-Xia,
Received Date: 1 September 2007
Available Online: 2 December 2007

MoCl₅ was found to activate the aromatic C-H bond,leading to in-situ C-C bond formation with high selectivity.A series of alkoxy-substituted aromatic compounds were coupled in para-position,in which it was not necessary to prepare the precursors:organometallics and ArX species.The present work provides a convenient method for the synthesis of pure symmetrical 4,4'-biaryls(e.g.,4,4'-dimethoxy-biphenyl,4,4'-diphenoxy-biphenyl,4,4'-dimethoxy-3,3'-dimethyl-biphenyl,2,3,2',3'-tetrahydro-[5,5']bibenzofuranyl,3,3'-dihydro-2,2'-dimethyl-[5,5']bibenzofuranyl,etc).Product structures were further verified by NMR and X-ray analysis.
- MoCl₅,
- aromatic C-H bond activation,
- in situ coupling reaction
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MoCl₅-Mediated Aromatic C-H Bond Activation and in situ C-C Bond Coupling Reaction