Citation: ZHANG Xue-Mei, OU Zhi-Bin, CHEN Shi, XIONG Ya-Hong, ZHOU Xiao-Hua, LIU Hai-Feng, LE Xue-Yi. Synthesis, Crystal Structure and DNA-Binding Properties of Copper(Ⅱ) Complex with 6-(Pyrazin-2′-yl)-1,3,5-triazine-2,4-diamine and Glycinate[J]. Chinese Journal of Inorganic Chemistry, ;2012, 28(12): 2667-2673. shu

Synthesis, Crystal Structure and DNA-Binding Properties of Copper(Ⅱ) Complex with 6-(Pyrazin-2′-yl)-1,3,5-triazine-2,4-diamine and Glycinate

1.
1. Department of Applied Chemistry, South China Agricultural University, Guangzhou 510642, China;

Corresponding author: LE Xue-Yi,
Received Date: 11 March 2012
Available Online: 8 July 2012
Fund Project: 广东省自然科学基金(No.10151064201000016) (No.10151064201000016)华南农业大学211工程重点项目(No.2009B010100001)资助项目. (No.2009B010100001)

The copper(Ⅱ) complex [Cu(H₂O)(Gly)(PZTA)]ClO₄ (Gly=glycinate) was prepared by the reaction of 6-(pyrazin-2′-yl)-1,3,5-triazine-2,4-diamine (PZTA) and glycine (Gly) with copper(Ⅱ) perchlorate, and characterized by elemental analysis, infrared radiation, UV-Vis, and molar conductance. Its crystal structure was determined by single crystal X-ray diffraction method. The complex crystallizes in the monoclinic system, space group C2/c, with cell parameters: a=2.189 6(3) nm, b=1.308 3(2) nm, c=1.465 4(4) nm, β=131.467(3)°, cell volume: V=3.145 6(9) nm³, number of molecules inside the cell: Z=8, final R indices (I>2σ(I)): R₁=0.037 4, wR₂=0.100 9. The interaction of the complex to DNA was studied by UV spectroscopy, EtBr fluoescent probe and viscosity measurement. The results indicate that the complex could interact with DNA by partial intercalative mode. CCDC: 848150.
- copper(Ⅱ) complex;6-(pyrazin-2′-yl)-1,3,5-triazine-2,4-diamine;glycine;crystal structure;DNA
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