Citation: Nan-Yang Chen, Li-Ping Ren, Min-Ming Zou, Zhi-Ping Xu, Xu-Sheng Shao, Xiao-Yong Xu, Zhong Li. Design, synthesis and insecticidal activity of spiro heterocycle containing neonicotinoid analogs[J]. Chinese Chemical Letters, ;2014, 25(2): 197-200. shu

Design, synthesis and insecticidal activity of spiro heterocycle containing neonicotinoid analogs

1.
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: Xu-Sheng Shao, Zhong Li,
Received Date: 23 September 2013
Available Online: 25 November 2013
Fund Project: This work was financial supported by National Basic Research Program of China (973 Program, No. 2010CB126100) (973 Program, No. 2010CB126100) National High Technology Research Development Program of China (863 Program, No. 2011AA10A207) (863 Program, No. 2011AA10A207) Key Projects in the National Science & Technology Pillar Program (No. 2011BAE06B05) (No. 2011BAE06B05) National Natural Science Foundation of China (No. 21372079) (No. 21372079) Shanghai Education Committee (No. 12ZZ057) (No. 12ZZ057)

Spiro heterocycles frequently occur in bioactive molecules. In the pursuit of neonicotinoids with spiro heterocycles, three types of novel neonicotinoids with spirobenzofuranone, spirooxindole or spiroacenaphythylenone framework were designed and synthesized. Insecticidal evaluation showed that some of spirobenzofuranone containing neonicotinoids exhibited moderate activity against cowpea aphid, armyworm or brown planthopper.
- Neonicotinoid,
- Spiro heterocycle,
- Activity,
- Insecticide
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沈阳化工大学材料科学与工程学院沈阳 110142