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Novel plant activators with thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate scaffold： Synthesis and bioactivity

Qing-Shan Du ,  Yan-Xia Shi ,  Peng-Fei Li ,  Zhen-Jiang Zhao ,  Wei-Ping Zhu ,  Xu-Hong Qian ,  Bao-Ju Li ,  Yu-Fang Xu

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Citation:  Qing-Shan Du, Yan-Xia Shi, Peng-Fei Li, Zhen-Jiang Zhao, Wei-Ping Zhu, Xu-Hong Qian, Bao-Ju Li, Yu-Fang Xu. Novel plant activators with thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate scaffold： Synthesis and bioactivity[J]. Chinese Chemical Letters, 2013, 24(11): 967-969. shu

Novel plant activators with thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate scaffold： Synthesis and bioactivity

    • 通讯作者: Bao-Ju Li,
    Yu-Fang Xu,
摘要: The 1,2,3-thiadiazole-carboxylate moiety was reported to be an important pharmacophore of plant activators. In this study, a series of novel plant activators based on thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate were designed and synthesized and their biological activity as plant activators was studied. The structures of the novel compounds were identified by 1H NMR, 19F NMR and HRMS. The in vivo bioassay showed that these novel compounds had good efficacy against seven plant diseases. Especially, compounds 1a and 1c were more potent than the commercialized plant activator BTH. Almost no fungicidal activity was observed for the active compounds in the in vivo assay, which matched the requirements as plant activators.

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  • 发布日期:  2013-09-14
  • 收稿日期:  2013-04-17
  • 网络出版日期:  2013-06-09
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