Citation: Bing Wang, Chi Ma, Zuo-Chun Xiong, Cheng-Dong Xiong, Quan-Hua Zhou, Dong-Liang Chen. Synthesis of novel copolymer：Poly(p-dioxanone-co-L-phenylalanine)[J]. Chinese Chemical Letters, ;2013, 24(05): 392-396. shu

Synthesis of novel copolymer：Poly(p-dioxanone-co-L-phenylalanine)

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a Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;
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b University of Chinese Academy of Sciences, Beijing 100049, China;
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c Sichuan Staff University of Science and Technology, Chengdu 610041, China

Corresponding author: Dong-Liang Chen,
Received Date: 26 December 2012
Available Online: 26 February 2013

In order to expand the application of poly(p-dioxanone) or PPDO in biomedical area, a series of novel copolymers were synthesized successfully by one-step, melted copolymerization of p-dioxanone (PDO) and L-phenylalanine N-carboxyanhydride (L-Phe-NCA) monomers. With the in-feedmolar ratio of L-Phe-NCA/PDO equal to 1/20, the conversions of the two kinds of monomers were calculated from ¹H NMR. The average molecular weight and polydispersity of the copolymer increase with the increasing reaction time and catalyst concentration. However, the conversions of the two kinds of monomers did not change with the reaction conditions. A three-step mechanism is presented and proved by high resolution ¹H NMR and IR spectrums.
- Copolymer,
- p-Dioxanone,
- L-Phenylalanine,
- Mechanism
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沈阳化工大学材料科学与工程学院沈阳 110142