Citation: Zhi-Wei Chen, Na Zhang, Zhi-Hua Wang, Wei-Ke Su. An efficient synthesis of novel chromeno[3’, 4’：5, 6]pyrano[2, 3-b]indole derivatives[J]. Chinese Chemical Letters, ;2013, 24(3): 199-201. shu

An efficient synthesis of novel chromeno[3’, 4’：5, 6]pyrano[2, 3-b]indole derivatives

1.
Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China

Corresponding author: Wei-Ke Su,
Received Date: 6 November 2012
Available Online: 4 January 2013

An efficient two-step method was described for the synthesis of chromeno[3',4':5,6]pyrano[2,3-b]indole derivatives. The three-component reaction of 4-hydroxycoumarin, variously substituted benzaldehydes and indolin-2-one was promoted by P₂O₅ in refluxing ethanol to give trimolecular adducts, which were then cyclized in 1,2-dichloroethane under reflux using POCl₃.
- Pyranochromene,
- Indolin-2-one,
- 4-Hydroxycoumarin,
- Multicomponent reaction,
- Intramolecular cyclization
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沈阳化工大学材料科学与工程学院沈阳 110142