Citation: Zhou Guoyong, Luo Yingchun, Li Heping. Progress in Polymer Nano Carriers for Improving Deep Tumor Penetration[J]. Chemistry, ;2017, 80(10): 891-899. shu

Progress in Polymer Nano Carriers for Improving Deep Tumor Penetration

Zhou Guoyong ^1,2,, ,
Luo Yingchun ¹ ,
Li Heping ^3,,

1.
School of Chemical Engineering(School of Chinese Pharmacy), Guizhou Minzu University, Guiyang 550025
2.
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275
3.
College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004

Corresponding author: Zhou Guoyong, gyzhou@vip.sina.com Li Heping, lhpp2008@163.com
Received Date: 18 February 2017
Accepted Date: 2 May 2017

Figures(9)

Over the last decades, remarkable progress has been made in the field of drug delivery in tumor.But, tumor therapy is still a tough nut to crack.However, in spite of significant advances to tumor targeting, an effective treatment strategy for malignant tumors still remains elusive.The research focus gradually shifted from the aggregation of carriers in the tumor to precise targeting and deep tumor penetration.How to overcome all obstacles to achieve its uniform distribution in the entire tumor tissue, to achieve an effective anti-tumor drug concentration are payed particular attention.In this paper, the mechanism of tumor tissue penetration were introduced, the effects of particles size, Zeta potential, particles shape, structure and chemical composition on tumor tissue penetration were discussed, and methods for assessing tumor tissue permeability were presented.The future research direction of this field was also prospected.
- Tumor penetration,
- Anticancer drug,
- Nano-carriers,
- Tumor therapy
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